Preparation method of 1-phenyl-2,2,2-trifluoroethylamine_Kain Industrial Additive
Background and overview[1] 1-Phenyl-2,2,2-trifluoroethylamine can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 1-phenyl-2,2,2-trifluoroethylamine is as follows: Synthesis of compound 4-b: Dissolve 4-a (1.00g, 5.74mmol, 781.25uL, 1.00eq) in EtOH (8.00mL) and water (4.00mL) at 25°C, then add hydroxylamine hydrochloride (598.31mg, 8.61mmol, 1.50 eq) and sodium acetate (941.70 mg, 11.48 mmol, 2.00 eq).…
Preparation method of 2,2,2-triphenylacetophenone_Kain Industrial Additive
Background and overview[1] 2,2,2-Triphenylacetophenone can be used as a pharmaceutical synthesis intermediate. If 2,2,2-triphenylacetophenone is inhaled, move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell. ; If eye contact occurs, separate eyelids, rinse with…
N-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-A]pyridine -2-yl]cyclopropanecarboxamide_Kain Industrial Additive
Background and overview[1] N-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5- A]pyridin-2-yl]cyclopropanecarboxamide can be used as a pharmaceutical synthesis intermediate. Preparation[1] N-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5- Preparation of A]pyridin-2-yl]cyclopropanecarboxamide (8A): 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborane- 2-yl)-benzyl)thiomorpholine 1,1-dioxide (Intermediate 1A) (20.18g, 53mmol), N-(5-bromo-[1,2,4]triazolo[1 ,5-a]pyridin-2-yl)cyclopropanecarboxamide (Intermediate 7A) (16.45g, 59mmol), Pd(dppf)Cl2 (3.91g, 5mmol), K2CO3 (22.06g, 160mmol) were added to 250mL in sequence into a three-necked flask, then add 1,4-dioxane (100 mL) and water…
Preparation method of 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride_Kain Industrial Additive
Background and overview[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride is prepared as follows: 1) Mix 2,3,5-trimethylphenol (50.03g, 0.367 mol), isoprene (25.09g, 0.368 mol) and molten zinc chloride (5.94g, 0.044 mol) with anhydrous Acetic acid (47ml) was stirred at room temperature for 14 hours. The cloudy red mixture is…
2,5-Dimethylbenzaldehyde-DNPH_Kain Industrial Additive
Background and overview[1] The 2,4-dinitrophenylhydrazine (DNPH) colorimetric method is a classic method for determining the carbonyl content of proteins. The oxidized protein carbonyl content increases, and the carbonyl group can react with 2,4-dinitrophenylhydrazine to form 2,4-dinitrophenylhydrazone, 2,4-dinitrophenylhydrazone is a reddish-brown precipitate. After dissolving the precipitate with guanidine hydrochloride, the absorbance value at 370nm can be…
Preparation of 2-benzyl-5-chloro-1,2,3,4-tetrahydro-[2,6]naphthyridine_Kain Industrial Additive
Background[1][2] 2-Benzyl-5-chloro-1,2,3,4-tetrahydro-[2,6]naphthyridine can be used as a pharmaceutical synthesis intermediate and an organic synthesis intermediate, mainly used in experiments Laboratory research and development process and chemical and pharmaceutical synthesis process. Preparation[1] 2-Benzyl-5-chloro-1,2,3,4-tetrahydro-[2,6]naphthyridine is prepared as follows: Step 1: N-ethoxy-3-methylpyridinium iodide: Add 3-methylpyridine-N-oxide (50.00g, 458mmol) and anhydrous dichloromethane (90mL) to the round-bottomed flask. Ethyl iodide (715.57g,…
Preparation of 4-(1,2,2-triphenylvinyl)benzoic acid_Kain Industrial Additive
Background and overview[1] 4-(1,2,2-triphenylvinyl)benzoic acid can be used in the field of organic chemistry, such as preparing an activated luminescent material, in which 4-(1,2,2-triphenylvinyl)benzoic acid is synthesized through a condensation reaction. Vinyl) benzoic acid is combined with different biomolecules to obtain biocompatible activated luminescent materials with AIE/AE characteristics. These biomolecules include highly fluorescent and water-soluble…
Preparation of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid_Kain Industrial Additive
Background and overview[1] 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid is a key intermediate in the synthesis of the cardiovascular drug flecainide. The existing technology is mainly obtained by the condensation of gentisic acid and trifluoroethyl trifluoromethanesulfonate. Since gentisic acid and trifluoroethyl trifluoromethanesulfonate are expensive, 2,5-bis(2,2 , 2-trifluoroethoxy)benzoic acid has a higher cost. Structure Preparation[1] A method for preparing 2,5-bis(2,2,2-trifluoroethoxy)benzoic…
Application of 3,4-dihydro-3-hydroxy-4-oxy-1,2,3-benzotriazine_Kain Industrial Additive
Background and overview[1] 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine is a heterocyclic organic compound and a polypeptide synthesis condensation agent, referred to as HOOBt. Compared with urea salts such as HBTU and HATU (phosphorus-(7-azabenyltriazol-1-yl)-1,1,3,3-tetramethylurea hexafluorophosphate), HOOBt is not only low in cost, but also more important What is unique is that in the condensation reaction, there is no side reaction…
2,6-Dimethylmorpholine
CAS: 141-91-3Boiling point: 147℃Chinese name: 2,6-dimethylmorpholine English name: 2,6-dimethylmorpholine2,6-dimethyl-2,3,5,6-tetrahydro-4h-1 ,4-oxazine2,6-dimethylmorfolin2,6-dimethylmorpholine 2,6-dimethyl-morpholin2,6-dimethylmorpholine, mixture of isomers
