3-dichloro-1-(4-nitrophenyl)-2-piperidone_Kain Industrial Additive

Background and overview[1] 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidone is an important pharmaceutical intermediate, for example, it can be used to prepare apixaban derivatives. Apixaban is a small molecule selective FXa inhibitor of pyrazole derivatives. Similar to rivaroxaban, apixaban has two binding sites for factor Xa. The 4-methoxyphenyl moiety in the apixaban structure binds to the S1 pocket of factor…