3]dioxole-4-carboxylic acid_Kain Industrial Additive

Background and overview[1] 5-Bromobenzo[1,3]dioxole-4-carboxylic acid can be used as a pharmaceutical synthesis intermediate. It can be prepared from 6-bromo-2,3-dihydroxybenzaldehyde in three steps. Preparation[1] Step 1: 6-bromo-2,3-dihydroxybenzaldehyde Dissolve 6-bromo-2-hydroxy-3-methoxybenzaldehyde (2.00g, 8.65mmol) in dichloromethane (10mL) and cool to 0°C. Boron tribromide (17.0 mL of a 1.0 M solution, 17.00 mmol) was added via syringe and the solution…