3S)-3-benzamido-2-hydroxy-3-phenylpropionic acid methyl ester_Kain Industrial Additives

Background and overview[1] (2R,3S)-3-Benzoylamino-2-hydroxy-3-phenylpropionic acid methyl ester can be passed through 3-hydroxy-4-phenylazetidin-2-one (HPA) It is prepared in two steps and can be used to prepare paclitaxel. Paclitaxel is a mitotic inhibitor or spindle poison and is a new type of anti-microtubule drug. Preparation[1] Step a, preparation of 3-phenylisoserine methyl ester hydrochloride Dissolve 50g of 3-hydroxy-4-phenylazetidin-2-one…