4-dichlorobenzamide_Kain Industrial Additives

Background and overview[1] 2,4-Dichlorobenzamide is a pharmaceutical intermediate that can be prepared from 2,4-dichlorobenzoic acid. Preparation[1] Method 1. Preparation of A. 2,4-dichlorobenzoyl chloride In a 1000mL single-neck bottle, dissolve 2,4-dichlorobenzoic acid (100.0g, 523.5mmol) in dry tetrahydrofuran (200mL), add 4 drops of dry N,N-dimethylformamide, and chloride Sulfoxide (93.4g, 785.3mmol). Reflux reaction for 5 hours. After the…