4-diphenyl-oxazacyclo-5-acid_Kain Industrial Additive

Background and overview[1] 2,4-Diphenyl-oxazacyclo-5-acid is a pharmaceutical intermediate that can be prepared in two steps from (2R,3S)-3-phenylisoserine and trimethyl orthobenzoate. get. It has been reported in the literature that 2,4-diphenyl-oxazacyclo-5-acid can be used to introduce substituents at the C-13 and C-14 positions of paclitaxel, retaining the ring skeleton and necessary functional groups of taxanes, and…