4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid_Kain Industrial Additive

Background and overview[1] (2R,4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl) Amino]-2-methylpentanoic acid is a key intermediate in the preparation of Sacubitril. Sacubitril and valsartan can form the compound drug Entresto at a ratio of 1:1. Entresto is a first-in-class medicine developed by Novartis to reduce the risk of cardiovascular death and hospitalization for heart failure and to reduce ejection fraction in…