Preparation of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid_Kain Industrial Additive
Background and overview[1] 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid is a key intermediate in the synthesis of the cardiovascular drug flecainide. The existing technology is mainly obtained by the condensation of gentisic acid and trifluoroethyl trifluoromethanesulfonate. Since gentisic acid and trifluoroethyl trifluoromethanesulfonate are expensive, 2,5-bis(2,2 , 2-trifluoroethoxy)benzoic acid has a higher cost. Structure Preparation[1] A method for preparing 2,5-bis(2,2,2-trifluoroethoxy)benzoic…
