5-dichlorophenylethylamine_Kain Industrial Additive

Background and overview[1] 2,5-Dichlorophenylethylamine can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2,5-Dichlorophenylethylamine was prepared as follows: To a solution of 2-(2,5-dichlorophenyl)acetonitrile (34.5g, 185mmol) in MeOH (1700mL) at 0°C, NiCl2 was added ·6H2O (4.45g, 18.7mmol). After 10 minutes, the solids from the initial green suspension went into solution. Methyl chloroformate (38.4 g, 406 mmol)…