Application of α-bromo-2,3,4,5,6-pentafluorotoluene_Kain Industrial Additive
Background and Overview α-Bromo-2,3,4,5,6-pentafluorotoluene is a benzene derivative that can be used as a derivatization reagent for gas chromatography analysis of multifunctional thiols, and can also be used to prepare pentafluorobenzene ester. Apply[1] α-Bromo-2,3,4,5,6-pentafluorotoluene can be used to prepare trithiocarbonate-bis(pentafluorobenzyl)ester: Reversible addition-fragmentation chain transfer polymerization (RAFT polymerization) is a typical controllable and living radical polymerization…
Application of [1,1′:4′,1″]terphenyl-3,3″,5,5″-tetracarboxylic acid_Kain Industrial Additive
Background and overview[1][2] [1,1′:4′,1″]terphenyl-3,3″,5,5″-tetracarboxylic acid is an aromatic hydrocarbon derivative that can be used to prepare various organic framework materials. Apply[1-2] 1. CN201710240032.2 provides a rare earth organic framework material for detecting vitamin C and a preparation method thereof. The rare earth organic framework material for detecting vitamin C of the present invention has a…
Application of 4-cyanomethyl-2,3,5,6-tetrafluorobenzonitrile_Kain Industrial Additive
Overview[1][2] 4-Cyanomethyl-2,3,5,6-tetrafluorobenzonitrile is a photochemical intermediate that can be prepared from hexafluorobenzonitrile in one step and can be used to synthesize luminescent materials. Preparation[1] Add hexafluorobenzonitrile (1.93g, 10mmol), ethyl cyanoacetate (1.11g, 10mmol), potassium carbonate (1.67g, 12.1mmol), and 30mL of DMF into the reactor, and stir for 48 hours at room temperature. Distilled water and acetic…
Preparation method of 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride_Kain Industrial Additive
Background and overview[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride is prepared as follows: 1) Mix 2,3,5-trimethylphenol (50.03g, 0.367 mol), isoprene (25.09g, 0.368 mol) and molten zinc chloride (5.94g, 0.044 mol) with anhydrous Acetic acid (47ml) was stirred at room temperature for 14 hours. The cloudy red mixture is…
How to prepare 3,4,5,6-tetrafluorophthalic acid_Kain Industrial Additive
Background and overview[1][2] 3,4,5,6-Tetrafluorophthalic acid, pure product is a white granular crystalline solid. This compound is mainly used as pharmaceutical intermediates and intermediates for the synthesis of fluorine-containing aromatic chemicals. It is a key intermediate for the preparation of ofloxacin and other fluoroquinolone antibiotics. CN102627553A, CN86106151, US5047553 and “Improvement of the Synthesis Process of Tetrafluorophthalic…
Preparation and application of 1,3,5,7-tetraphenyladamantane_Kain Industrial Additive
Background and overview[1] 1,3,5,7-tetraphenyladamantane is an organic intermediate, which can be used to prepare a new aromatic sulfonate flame retardant-adamantyl-1,3,5,7-tetraphenyl Sodium phenyl sulfonate. Adamantyl-1,3,5,7-tetra-p-phenylsulfonate sodium has a highly symmetrical structural feature. One adamantyl-1,3,5,7-tetra-p-phenylsulfonate sodium molecule contains 4 pairs of The expected flame retardant effect of the sodium benzene sulfonate group should far exceed that of…
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H -Preparation of ethyl pyrazolo[3,4-C]pyridine-3-carboxylate_Kain Industrial Additive
Background and overview[1] 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra Hydro-1H-pyrazolo[3,4-C]pyridine-3-carboxylic acid ethyl ester is an intermediate for the preparation of apixaban, an antithrombotic drug produced by Bristol-Myers Squibb in the United States. -The factor Xa direct inhibitor jointly developed by Bristol-Myers Squibb and Pfizer was approved for marketing in the EU in March 2011, and the FDA approved the drug…
Application of 2-(2-difluoromethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborane_Kain Industrial Additive
Background and Overview 2-(2-Difluoromethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborane is an organic intermediate commonly used in metal catalysis coupling reaction, Application examples[1-2] Report 1, CN201780052527.0 reported that 2-(2-difluoromethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborane can be used to synthesize compound 6-amino -N-(5-chloro-6-(2-(difluoromethyl)phenyl)pyridin-2-yl)pyridine-2-sulfonamide. This compound is a CF transmembrane conductance regulator (CFTR) corrector. Cystic fibrosis (CF) is caused by loss-of-function mutations in the CF transmembrane conductance regulator…
Preparation and application of 2,4,5,6-tetrafluoroisophthalonitrile_Kain Industrial Additive
Background and overview[1] 2,4,5,6-tetrafluoroisophthalonitrile can be used as a pharmaceutical synthesis intermediate, such as the preparation of dichloruron, which is an insect growth regulator, and the better representative is dichloruron. . Chemuron has the following advantages: 1. Unique mechanism of action, low toxicity to beneficial organisms, easy to degrade, high selectivity, relatively safe, and is…
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2-[3-(morpholino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS: 852227-95-3Chinese name: 4-[3-(4,4,5, 5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine3-(morpholino)phenyl Pinacol borate2-[3-(morpholino)phenyl]-4,4,5,5-tetramethyl-1,3,2 -DioxaborolaneEnglish name: 4-[3-(4,4,5, 5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine3-(morpholino)phenylboronic acid pinacol ester 2-[3-(morpholino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
