6-diphenyl-2-hydroxypyrazine_Kain Industrial Additive

Background and overview[1] 5,6-Diphenyl-2-hydroxypyrazine is a pharmaceutical intermediate that can be prepared in one step from benzoyl and aminoacetamide hydrochloride. There are reports in the literature that 5,6-diphenyl-2-hydroxypyrazine can be used to prepare IP receptor agonists (Compound I). The diseases that IP receptor agonists can treat mainly include pulmonary arterial hypertension (PAH), PAH related to…