8-pentamethylchroman-6-sulfonyl chloride_Kain Industrial Additive

Background and overview[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride is prepared as follows: 1) Mix 2,3,5-trimethylphenol (50.03g, 0.367 mol), isoprene (25.09g, 0.368 mol) and molten zinc chloride (5.94g, 0.044 mol) with anhydrous Acetic acid (47ml) was stirred at room temperature for 14 hours. The cloudy red mixture is…