Application of 1-(3-methylphenyl)piperazine dihydrochloride_Kain Industrial Additive

Overview[1] 1-(3-methylphenyl)piperazine dihydrochloride is a pharmaceutical intermediate, which is the hydrochloride form of 1-(3-methylphenyl)piperazine. It can be synthesized from 1-(3 -Methylphenyl)piperazine is prepared from hydrogen chloride. Preparation method[1] The general route to prepare 1-(3-methylphenyl)piperazine is as follows. Reaction conditions: a.SOCl2, rt, 14-15h; b. 3-methylaniline, MW, 170℃-180℃, 30-45min The specific operations are as follows: Synthesis of…