Application of 2,4-dichlorophenylacetic acid_Kain Industrial Additive

Background and overview[1][2] 2,4-Dichlorophenylacetic acid is a key intermediate for the new insecticide and acaricide spirodiclofen. Spirobifen is a kind of insecticide and acaricide developed by the company, such as oxobutyrolactone with a cyclic ketone structure. It is an active ingredient of “mite hazard”. Spirobifen has the same Existing acaricides have a completely different mechanism…

Application of 2,3-difluorotoluene_Kain Industrial Additive

Background and overview[1][2] 2,3-Difluorotoluene can be used as an intermediate for pharmaceutical and chemical synthesis. If 2,3-difluorotoluene is inhaled, move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel uncomfortable; if there is eye contact…

Application of 2,4-dichloro-5-methoxyaniline_Kain Industrial Additive

Background and overview[1] 2,4-Dichloro-5-methoxyaniline CAS number 98446-49-2, chemical formula C7H7Cl2NO. Molecular weight 247.06100. White or off-white powder, density 1.375 g/cm3, melting point 51 °C, boiling point 290.1ºC at 760 mmHg, flash point 129.3ºC, refractive index 1.587. 2,4-Dichloro-5-methoxyaniline is mainly used in the preparation of primary Sutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile . Bosutinib, developed by Wyeth Pharmaceuticals in…

Application of 2,4-dibromobenzoic acid_Kain Industrial Additive

Background and Overview 2,4-Dibromobenzoic acid is a chemical intermediate with the molecular formula C7H4Br2O2. . Preparation[1-3] Method 1, CN02821215.0 discloses the two-step preparation of 2,4-dibromobenzoic acid from 2,4-dibromoaniline The first step: 2,4-dibromobenzonitrile At 60°C, add copper cyanide (2.32g, 25.9mmol) to stirring anhydrous dimethyl sulfoxide (50mL) to form a clear solution, then add tert-butyl nitrite (7.1mL)…

Application of 2,4-dimethylphenol_Kain Industrial Additive

Background and overview[1][2] 2,4-Dimethylphenol, needle-like crystal. The melting point is 27-28℃, the boiling point is 211.0℃, the relative density is 0.9650 (20/4℃), and the refractive index is 1.5420 (14℃). Miscible with alcohol and ether, slightly soluble in water. Preparation[1] CN201810102442.5 provides a separation process for extracting 2,4-dimethylphenol from crude phenol. The specific steps are as…

Application of 2,5-diamino-1,4-benzenedithiophene dihydrochloride_Kain Industrial Additive

Background and overview[1][2] 2,5-Diamino-1,4-benzenedithiophene dihydrochloride can be used as an organic solvent and as an intermediate in organic synthesis. If 2,5-diamino-1,4-benzenedithiophene dihydrochloride is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and wash the skin thoroughly with soap and water. If you feel any discomfort, seek medical attention; if…

Application of 2,3-dichlorophenylhydrazine hydrochloride_Kain Industrial Additive

Background and overview[1] Phenylhydrazine was first synthesized by Hermann Emil Fischer in 1875 and was the first hydrazine derivative synthesized. With the deepening of research on heterocyclic compounds and the continuous expansion of applications, substituted phenylhydrazine compounds have a wide range of applications. In medicine, they can synthesize new antibacterial drugs, treat diabetes, anticancer drugs,…

Application of 2,4-dichlorophenylhydrazine_Kain Industrial Additive

Background and overview[1] 2,4-Dichlorophenylhydrazine is an important chemical raw material. The current preparation methods of 2,4-dichlorophenylhydrazine cannot avoid operations such as diazotization, sulfonation, and reduction of 2,4-dichloroaniline. These operations have high requirements on reaction temperature, and diazotization must be Low-temperature reaction, and poor control of the dripping speed and reaction degree of the sodium nitrite…

Application of 2,4,6-Trichlorobenzaldehyde_Kain Industrial Additive

Background and overview[1] 2,4,6-Trichlorobenzaldehyde can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 2,4,6-trichlorobenzaldehyde is as follows: The specific steps are as follows: Under argon protection and minus 78 degrees Celsius, add 10.0g (55.1mmol) 1,3,5-trichlorobenzene and 100ml ultra-dry tetrahydrofuran into a 250ml single-neck flask. Then add 23ml (2.4M, 55.2mmol) n-butyllithium n-hexane solution…

Application of 2,3,4,6-Tetrachlorophenol_Kain Industrial Additive

Background and overview[1] Arsenic atomic absorption standard, also known as 2,3,4,6-tetrachlorophenol in Chinese, can be used as a pharmaceutical synthesis intermediate. Chlorophenols are a typical class of “three-causing (carcinogenic, teratogenic, mutagenic)” organic pollutants and are widely used in the production of preservatives, dyes, herbicides and pesticides. At the same time, chlorophenols by-products may also be…

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