Application of 2-bromo-4-chloro-3-fluorobenzoic acid_Kain Industrial Additive

Background and overview[1] 2-Bromo-4-chloro-3-fluorobenzoic acid is an acid derivative that can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2-Bromo-4-chloro-3-fluorobenzoic acid: A solution of 4-chloro-3-fluorobenzoic acid (2.0g, 11.46mmol) in THF (25ml) was passed through a syringe pump at -78°C for 30 minutes. Add to a solution of LDA (13.18 ml, 26.4 mmol) in THF (50…