Application of 2-fluoro-3-(trifluoromethyl)phenol_Kain Industrial Additive

Background and overview[1] 2-Fluoro-3-(trifluoromethyl)phenol is an organic fluoride that can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 2-fluoro-3-(trifluoromethyl)phenol is as follows: Under a nitrogen atmosphere, put compound (t-20) (24.5g, 149.30mmol) and THF (300mL) into a reaction vessel, and cool to -70°C or lower. Then, n-butyllithium (1.60 M; n-hexane solution; 111.97 mL,…