Application of 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid_Kain Industrial Additive

Background and overview[1][2] 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid is a key intermediate for the antibiotic flucloxacillin sodium. Also known as Flucloxacillin – Impurity D. The existing chemical synthesis method of 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid uses phosphorus oxychloride as the chlorination reagent, which is harmful to the equipment. The corrosion is serious, and the large amount of phosphorus-containing wastewater in the…