Application of 5-phenylisoxazole-3-carboxylic acid ethyl ester_Kain Industrial Additive

Background and overview[1][2] Ethyl 5-phenylisoxazole-3-carboxylate is an organic chemical intermediate that can be prepared from phenylacetylene or ethyl 2,4-dioxo-4-phenylbutyrate as starting materials. . Preparation[1-2] Method 1, Phenylacetylene (20g, 0.2mol) and ethyl nitroacetate (66.4g, 0.5mol) were dissolved in 500ml of chloroform, and then 11.2g of triethylenediamine (DABCO, 0.1mol) was added. The solution was heated to 70°C…