Application of ethyl 4-boron-3-chlorobenzoate_Kain Industrial Additives

Background and overview[1] Ethyl 4-boron-3-chlorobenzoate can be used as a pharmaceutical synthesis intermediate and applied in Suzuki coupling reaction. CN107207488 reports that ethyl 4-boron-3-chlorobenzoate can be used to prepare 3-chloro-4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-thiodi Azol-3-yl)benzoic acid, a compound that selectively activates retinoic acid receptor beta (RARβ) (eg, RARβ2) in vitro or in vivo. Application examples[1] Preparation of methyl 3-chloro-4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-thiadiazol-3-yl)benzoate:…