Application of methyl 3,4-dimethoxy-5-hydroxybenzoate_Kain Industrial Additive
Background and overview[1] Methyl 3,4-dimethoxy-5-hydroxybenzoate is an ester derivative and an important intermediate in the synthesis of acotiamide. Acotiamide hydrochloride, chemical name is N-{2-bis(1-methylethyl)aminoethyl}-2-(2-hydroxy-4,5-dimethoxybenzoyl) ) Aminothiazole-4-carboxamide hydrochloride, which is a new type of M1 and M2 receptor antagonist developed by Japan’s Zeria New Pharmaceutical Co., Ltd., was launched in Japan on June 6, 2013 by…
Application of methyl 3,4-dimethoxyphenylacetate_Kain Industrial Additive
Background and overview[1][2] Methyl 3,4-dimethoxyphenylacetate, also known as methyl homoveratrate, can be used to synthesize the beta-blocker bevantolol and the antiarrhythmic drug verapamil. verapamil), etc., are also key intermediates in the synthesis of isoquinoline alkaloids. The traditional synthesis method is to react 3,4-dimethoxybenzyl chloride with cyanide to obtain 3,4-dimethoxyphenylacetonitrile, and then hydrolyze it to obtain…
