Application of p-tert-butylphenylhydrazine hydrochloride_Kain Industrial Additive

Background and overview[1] p-tert-Butylphenylhydrazine hydrochloride is a phenylhydrazine derivative and can be used as a pharmaceutical synthesis intermediate. Preparation[1] p-tert-Butylphenylhydrazine hydrochloride is prepared as follows: add 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide (5.87ml) to 4-isopropyl under ice cooling. In a mixture of phenylhydrazine hydrochloride (5.0g), acetic acid (1.84ml), triethylamine (3.73ml) and 1-hydroxybenzotriazole hydrate (40.4mg) in dichloromethane (50ml), then The mixture…