How to prepare 4-nitrobenzene acetylene_Kain Industrial Additive

Background and overview[1] 4-Nitrophenylacetylene is an organic intermediate that can be prepared from 1-iodo-4-nitrobenzene in two steps. Preparation[1] Step 1 Preparation of [4-(nitrophenyl)ethynyl]trimethylsilane (S7g) To 1-iodo-4-nitrobenzene (S6) (1.00 g, 4.02 mmol), Pd(PPh3)2Cl2 (84.3 mg, 0.120 mmol), CuI (45.7) and Et3N (2.24 mg, 16.4 mmol) Add (trimethylsilyl)acetylene (560 mg, 4.06 mmol) to 6.8 ml of DMF…