Main applications of 5-fluoro-2-methylphenylmagnesium bromide_Kain Industrial Additive

Background and overview[1] 5-Fluoro-2-methylphenylmagnesium bromide can be used as a pharmaceutical synthesis intermediate. Preparation[1] Generation of Grignard reagent 5-fluoro-2-methylphenylmagnesium bromide in a single CSTR: Activate a slurry of magnesium (227g, 9.4mol) in MeTHF (1L) to prepare 1.0MINT1 Grignard reagent (1207g) , occurs immediately after activating stirring. To compound 1 (23% (w/w)), MeTHF was added to…