Preparation and application of 1-(3-bromophenyl)pyrrole_Kain Industrial Additive

Background and overview[1] 1-(3-Bromophenyl)pyrrole is an important pharmaceutical intermediate. For example, it can be used to prepare lithium 3-(pyrrolidin-1-yl)benzenesulfinate from 1,3-dibromobenzene. Prepared by reaction with pyrrolidine. Preparation[1] Synthesis of 1-(3-bromophenyl)pyrrole: Add 1,3-dibromobenzene (20g, 84.78mmol, 1.00 equiv) in toluene (300 mL). To this was added pyrrolidine (6.03g, 84.80mmol, 1.00equiv). Pd(OAc)2 (190 mg, 0.85 mmol, 0.01 equiv)…