Preparation and application of 1-bromo-3-fluoro-5-pyrrolidinebenzene_Kain Industrial Additive

Background and overview[1] 1-Bromo-3-fluoro-5-pyrrolidine benzene is a pharmaceutical intermediate, which can be prepared by nucleophilic substitution of 1-bromo-3,5-difluorobenzene and pyrrolidine. 1-Bromo-3-fluoro-5-pyrrolidinebenzene can be used to prepare phenyl (4-(3-(pyrrolidin-1-yl)-5-fluorophenyl])piperazin-l-yl)methanone, An anti-amyloid compound. Preparation[1] Add 1-bromo-3,5-difluorobenzene (1.00g, 5.18mmol), pyrrolidine (0.47mL, 5.7mmol), DEPEA (1.4mL, 7.77mmol) and NMP (6.9mL) to the tube middle. The tube was sealed and stirred…