Preparation and application of 2-cyano-5-fluorobenzoic acid_Kain Industrial Additive

Overview[1] 2-Cyano-5-fluorobenzoic acid is an organic intermediate that can be prepared from 2-bromo-5-fluorobenzoic acid methyl ester in two steps. Preparation[1] Step a: Heat a mixture of 2-bromo-5-fluorobenzoic acid methyl ester (5.00g, 21.5mmol) and copper cyanide (2.12g, 23.6mmol) in DMF at 90°C for 1 day. Then cool to room temperature, dilute with ethyl acetate (300 mL)…