Preparation and application of 2-hydroxy-5-trifluoromethylbenzoic acid_Kain Industrial Additive

Background and overview[1] 2-Hydroxy-5-trifluoromethylbenzoic acid is an organic intermediate that can be prepared by the reaction of 2-methoxy-5-(trifluoromethyl)benzoic acid and iodocyclohexane. Preparation[1] Place 2-methoxy-5-(trifluoromethyl)benzoic acid (5.00g, 22.71mmol) in a flask containing iodocyclohexane (29.4mL, 227mmol) and DMF (25mL). The reaction mixture was refluxed for 4 h, cooled, and the solvent was removed in vacuo. The crude…