Preparation and application of 3-bromo-2-fluorobenzonitrile_Kain Industrial Additive

Background and overview[1] 3-Bromo-2-fluorobenzonitrile is an organic intermediate that can be prepared from 3-bromo-2-fluorobenzoic acid in two steps. 3-Bromo-2-fluorobenzonitrile can be used as a pharmaceutical intermediate for the preparation of STK4 inhibitors. Preparation[1] Step 1, preparation of 3-bromo-2-fluorobenzamide (2-80) 3-Bromo-2-fluorobenzoic acid (2-79, 400 mg, 1.83 mmol) and SOCl2 (4.39 mg, 3.66 mmol) were dissolved in…