Preparation and application of 3-ethynyl anisole_Kain Industrial Additive
Background and overview[1] 3-Ethynyl anisole is an ether derivative and can be used as a pharmaceutical synthesis intermediate. Preparation[1] 3-Ethynyl anisole is prepared as follows: 1) To 3-bromoanisole (5mL, 39.5mmol, 1 equivalent), triethylamine (22mL, 158mmol, 4 equivalents), CuI (0.75g, 4.0mmol, 10mol%) were added to toluene (50mL) Pd(PPh3)2Cl2 (1.4 g, 2.0 mmol, 5 mol%) in (trimethylsilyl)acetylene…