Preparation and application of 3-fluoro-4-nitrotoluene_Kain Industrial Additive

Background and overview[1] 3-Fluoro-4-nitrotoluene can be used as a pharmaceutical synthesis intermediate. It can be obtained by one-step nitration of 3-fluorotoluene. Preparation[1] 3-Fluoro-4-nitrotoluene is prepared as follows: The specific steps are as follows: While stirring 160cm3 of concentrated nitric acid on an ice bath, add 160cm3 of concentrated sulfuric acid dropwise below 10°C. Add 90g…