Preparation and application of 4-bromobenzenesulfonamide_Kain Industrial Additive

Background and overview[1] 4-Bromobenzenesulfonamide can be used as a pharmaceutical synthesis intermediate. It can be prepared by the reaction of 4-bromobenzenesulfonyl chloride and ammonia water, or it can be prepared in one step from p-bromobenzene tetrafluoride boron diazonium salt. Preparation[1-2] Method 1: Under nitrogen protection, p-bromobenzene tetrafluoride boron diazonium salt (338.5mg, 1.25mmol), NaN3 (32.5mg, 0.5mmol),…