Preparation and application of 4-chloro-3-fluorophenol_Kain Industrial Additive

Background and overview[1] 4-Chloro-3-fluorophenol is an organic intermediate. 4-amino-3-fluorophenol can be prepared from o-fluoronitrobenzene as raw material, and then acyl chlorination reaction can occur to prepare 4-chloro-3-fluorophenol. . 4-Chloro-3-fluorophenol can further prepare the pharmaceutical intermediate 4-chloro-3-fluoroanisole. Preparation[1] (1) Mix deionized water and absolute ethanol and add concentrated sulfuric acid dropwise. Finally, add o-fluoronitrobenzene and catalyst…