Preparation and application of 4-chloropropiophenone_Kain Industrial Additive

Background and overview[1] 4-Chloropropiophenone is an aromatic asymmetric ketone compound. It is a white crystalline solid with a melting point of 34-37°C. 4-Chloropropiophenone is an important intermediate that plays a structural role. Mainly used as a pharmaceutical intermediate for the synthesis of new weight loss drug rimonabant (N-(piperidine)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4- Methyl-IH-pyrazole-3carboxamide) key intermediates α-bromo-4-chloropropiophenone and 4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid…