Preparation and application of 5-chloro-2-hydroxyacetophenone_Kain Industrial Additive

Background and overview[1] 5-Chloro-2-hydroxyacetophenone can be nitrated to prepare 5-chloro-2-hydroxy-3-nitroacetophenone. 5-Chloro-2-hydroxy-3-nitroacetophenone is a key drug intermediate for the synthesis of pranlukast, which has potential application value in new drug research. Plunkast was pioneered by Japan’s Ono Pharmaceutical Co., Ltd. The world’s first leukotriene receptor antagonist was launched in Japan in 1995. Registered in Europe and…