Preparation and application of 6

Background and overview[1] 6,7-Dihydro-4(5H)-benzofuranone is an important pharmaceutical intermediate. It can be prepared by the reaction of 1,3-cyclohexanedione and chloroacetaldehyde aqueous solution, and can be used to synthesize 5 -Acetyl-6,7-dihydro-4(5H)-benzofuranone. Preparation[1] Synthesis of 6,7-dihydro-4(5H)-benzofuranone: Add 1,3-cyclohexanedione (10.0g, 89.18mmol) to a 250mL round-bottomed flask, and dissolve it in 60mL of water. Add 35 mL of 20%…