Preparation and application of ethyl 3-nitrophenyl acetate_Kain Industrial Additive

Background and overview[1] Ethyl 3-nitrophenylacetate can be used as a pharmaceutical synthesis intermediate. It can be prepared by the esterification reaction of 3-nitrophenylacetic acid and ethanol. It can be used as a raw material to prepare 2-[3-(3- Methyl-but-2-enoylamino)-phenyl]-heptanoic acid ethyl ester. Preparation[1] A solution of 3-nitrophenylacetic acid (12.755g, 70.4mmole) in 150mL ethanol was treated with…