Preparation and application of methyl 2-(tert-butoxy-2-carboxamide)-3-nitrobenzoate_Kain Industrial Additive

Background and overview[1] Methyl 2-(tert-butoxy-2-carboxamide)-3-nitrobenzoate is a pharmaceutical intermediate that can be used in the synthesis of candesartan. Candesartan and candesartan cilexetil are a new type of non-peptide angiotensin II (ATII) receptor antagonist, which is clinically used for the treatment of hypertension. The drug was first launched in Sweden in 1997. Preparation[2] Methyl 2-(tert-butoxy-2-carboxamide)-3-nitrobenzoate is…