Preparation method and application of 2-methoxy-5-sulfonamide benzoic acid methyl ester_Kain Industrial Additive

Background and overview[1] Methyl 2-methoxy-5-sulfonamide benzoate is an important intermediate for the antipsychotic drugs sulpiride and levosulpiride. Its synthesis currently uses salicylic acid through methylation, chlorosulfonation, This product is obtained through amination and esterification. The process route is long and each step produces a large amount of three wastes, especially high chemical oxygen demand (COD),…