Preparation method of 1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one_Kain Industrial Additive

Background and overview[1] 1-(2-Fluoro-3-hydroxy-6-nitrophenyl)propan-2-one can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one is as follows: Step 1): 1-(2,3-difluoro-6-nitrophenyl)propan-2-one (compound 302) To a suspension of sodium hydride (5.42g, 226mmol) in THF (100mL) was added ethyl acetoacetate (29.4g, 226mmol) while maintaining the reaction temperature below 15°C. Stir the mixture for 15 minutes.…