Preparation method of 1-chloro-4-(4-phenyl-1

Background and overview[1] 1-Chloro-4-(4-phenyl-1,3-butadiene)benzene can be used as a pharmaceutical synthesis intermediate. Preparation[1] 1) Synthesis of bisethyl-4-chlorobenzylphosphine Preparation process: Preparation of bisethyl-4-chlorobenzylphosphine: 1-chloro-4-(chloromethyl)benzene (50g, 0.31mol) and triethyl phosphite (74.9g, 0.47mol) Add to a 200 ml flask, heat to reflux and stir for 7 hours. The mixture is cooled to room temperature, and excess triethyl phosphite…