Preparation method of 2-amino-3-fluorophenol_Kain Industrial Additive

Background and Overview 2-Amino-3-fluorophenol is a phenol derivative and can be used as a pharmaceutical intermediate. Preparation method[1-2] Method 1, Step 1 1-fluoro-3-methoxy-2-nitrobenzene: To a solution of 1,3-difluoro-2-nitrobenzene (100g, 0.63mol) in MeOH (1.3L) at 0°C, slowly add MeONa solution (0.69mol, in MeOH, composed of 15.9g metallic sodium and 200 mL MeOH freshly prepared). The resulting…