Preparation method of 2-bromo-1-(4-morpholinophenyl)-1-ethanone_Kain Industrial Additive

Background and overview[1] 2-Bromo-1-(4-morpholinophenyl)-1-ethanone can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 2-bromo-1-(4-morpholinophenyl)-1-ethanone is as follows: 1) Preparation of intermediate 4-morpholinophenylethanone Take 50g of 4-fluoroacetophenone, dissolve it in 350mL of dimethyl sulfoxide (DMSO) (about 7 to 8 times mass to volume ratio), stir evenly, and it will become a colorless solution.…