Preparation method of 2,2,2-triphenylacetophenone_Kain Industrial Additive
Background and overview[1] 2,2,2-Triphenylacetophenone can be used as a pharmaceutical synthesis intermediate. If 2,2,2-triphenylacetophenone is inhaled, move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell. ; If eye contact occurs, separate eyelids, rinse with…
Preparation method of 2,2-bis(3-aminophenyl)hexafluoropropane_Kain Industrial Additive
Background and overview[1] Bis(ethynylphenyl) compounds, also known as ethynylated bisaryl derivatives, are important intermediates for the synthesis of thermally stable resins, used in high-temperature structural composites and high-carbon-yielding structural matrices, such as carbon-carbon composite materials. These materials are used in the manufacture of re-entry missile nose cones, leading edges, rocket nozzles and other structural applications…
Preparation method of 2,4-dichloro-6-fluorobenzaldehyde_Kain Industrial Additive
Background and overview[1] 2,4-Dichloro-6-fluorobenzaldehyde can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 2,4-dichloro-6-fluorobenzaldehyde is as follows: To a solution of 1,3-dichloro-5-fluorobenzene (2.0g, 12mmol) in tetrahydrofuran (20mL) at -70°C, lithium diisopropylamide (2M solution in tetrahydrofuran, 18mmol) was added dropwise. 9.1mL). The reaction was stirred at -70 °C for 0.5 h, then N,N-dimethylformamide…
Preparation method of 2,5-dimethyl-4-hydroxybenzonitrile_Kain Industrial Additive
Background and overview[1] 2,5-Dimethyl-4-hydroxybenzonitrile can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 2,5-dimethyl-4-hydroxybenzonitrile is as follows: The specific steps are: 1) Dissolve 0.02 mol of 2,5-dimethylphenol and equal amounts of sodium iodide and sodium hydroxide in 50 mL of methanol. Cool the solution in an ice bath until the temperature reaches…
Preparation method of 2,6-dichloro-3-(trifluoromethyl)benzoic acid_Kain Industrial Additive
Background and overview[1] 2,6-Dichloro-3-(trifluoromethyl)benzoic acid is an organic intermediate that can be prepared from 2,4-dichloro-1-(trifluoromethyl)benzoic acid through a two-step reaction. . Starting from 2,4-dichlorotrifluorotoluene, the reaction was continuously treated with butyllithium and dry ice to obtain 2,6-dichloro-3-(trifluoromethyl)benzoic acid with a yield of 75%. Preparation method[1] A solution of 2,4-dichloro-1-(trifluoromethyl)benzene (3.6 mL, 5.4 g, 25 mmol)…
Preparation method of 2,5-dichlorophenylethylamine_Kain Industrial Additive
Background and overview[1] 2,5-Dichlorophenylethylamine can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2,5-Dichlorophenylethylamine was prepared as follows: To a solution of 2-(2,5-dichlorophenyl)acetonitrile (34.5g, 185mmol) in MeOH (1700mL) at 0°C, NiCl2 was added ·6H2O (4.45g, 18.7mmol). After 10 minutes, the solids from the initial green suspension went into solution. Methyl chloroformate (38.4 g, 406 mmol)…
Preparation method of 2,6-dimethoxyhydroquinone_Kain Industrial Additive
Background and overview[1] 4-Bromoquinoline-6-carboxylic acid can be used as a pharmaceutical synthesis intermediate. Such as preparing scutellarin intermediate scutellarin aglycone. Erigerm breviscapus (Vant.) Hand-Mass, commonly known as Erigerm breviscapus, is the dried whole plant of the Asteraceae plant Erigermbreviscapus (Vant.) Hand-Mass. It was first seen in “Southern Yunnan Materia Medica” written by Lan Zhi’an, a…
Preparation method of 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride_Kain Industrial Additive
Background and overview[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride is prepared as follows: 1) Mix 2,3,5-trimethylphenol (50.03g, 0.367 mol), isoprene (25.09g, 0.368 mol) and molten zinc chloride (5.94g, 0.044 mol) with anhydrous Acetic acid (47ml) was stirred at room temperature for 14 hours. The cloudy red mixture is…
Preparation method of 2,4-dichlorobenzoyl peroxide_Kain Industrial Additive
Background and overview[1] It is well known that diacyl peroxides can be produced by reacting acid chlorides and hydrogen peroxide in alkaline solutions, but it is difficult to produce powdered products and has problems such as low content and low yield. The preparation method of 2.4-dichlorobenzoyl peroxide (DCPB for short) is to prepare paste DCPB,…
