Preparation method of 3-acetonitrilecyclobutylamine hydrochloride_Kain Industrial Additive

Background and overview[1] 3-Acetonitrilecyclobutylamine hydrochloride can be used as a pharmaceutical synthesis intermediate. Preparation[1-2] Method 1: 3-acetonitrilecyclobutylamine hydrochloride is prepared as follows: Compound BB-30-1 (0.200g, 1.10mmol) was dissolved in dichloromethane (2mL), and then hydrogen chloride dioxane solution (1mL, 4M) was added. The reaction solution was stirred at 20°C for 2 hours. The reaction solution was…