Preparation method of 3-phenylisoxazole-5-carboxylic acid_Kain Industrial Additive

Background and overview[1] 3-phenylisoxazole-5-carboxylic acid can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 3-phenylisoxazole-5-carboxylic acid is divided into the following steps: Step 1: 5-(4-fluorophenyl)-N-(2-morpholinoethyl)isoxazole-3-carboxamide A stirred solution of 5-(4-fluorophenyl)isoxazole-3-carboxylic acid (0.1g, 0.48mmol) and 2-morpholinoethyl-1-amine (0.127g, 0.97mmol) The dichloromethane (5 mL) solution was cooled to 0 °C. Pyridine (0.2 mL) was added…