Preparation method of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride_Kain Industrial Additive

Background and overview[1] 4-(4-Methyl-1-piperazinylmethyl)benzoic acid dihydrochloride is a key intermediate for the preparation of imatinib mesylate. Imatinib mesilate, chemical name is 4-(4-methylpiperazinyl-1-methyl)-N-[4-methyl-3-[4-(3-pyridyl) Pyrimidine-2-amino]-benzamide methanesulfonate. Imatinib mesylate is a small molecule tyrosine kinase (TK) inhibitor. Its mechanism of action is to target the bcr/abl receptor subtype of tyrosine kinase and selectively bind to bcr/abl protein tyrosine…