Preparation method of 4-aminomethylbenzoic acid methyl ester hydrochloride_Kain Industrial Additive

Background and overview[1-2] 4-Aminomethylbenzoic acid methyl ester hydrochloride is a pharmaceutical intermediate, which can be prepared from 4-aminomethylbenzoic acid through one-step esterification, or from 4-(bromomethyl)benzoic acid methyl ester Prepared in two steps. Preparation[1-2] Report 1, Dissolve 10g (151g/mol, 0.066mol) 4-aminomethylbenzoic acid in 150ml methanol, and slowly add 7.15ml (118g/mol, 1.64g/ml, 0.099mol) into the solution under…