Preparation method of 4-fluoro-3-methylbenzoic acid_Kain Industrial Additive

Background and overview[1][2] 4-Fluoro-3-methylbenzoic acid is an important fluorine-containing medicine, pesticide, and dye intermediate, such as used in the synthesis of anti-inflammatory and antibacterial drugs, local anesthetics for surgery, organofluorine pesticides, Herbicides, plant growth regulators, etc. 4-Fluoro-3-methylbenzoic acid was synthesized in two steps using isobutyllithium, p-fluorobenzoic acid, and methyl iodide at -78°C. This method has…