Preparation method of 5-chloro-3-benzofuranone_Kain Industrial Additive

Background and overview[1][2] 5-Chloro-3-benzofuranone is a ketone derivative and can be used as a pharmaceutical synthesis intermediate. Preparation method[1] 5-Chloro-3-benzofuranone was prepared as follows: phenol derivative (0.5 mol) (R: 5-chloro) and acetic anhydride (0.6 mol) were refluxed with pyridine for 30 minutes, and then the reaction mixture was cooled with Treat the water, filter the…