Preparation method of deuterated acetophenone_Kain Industrial Additive

Overview[1] Deuterated acetophenone is a deuterated reagent that can be prepared from benzene-d6 in two steps. Preparation method[1] Step 1: Preparation of acetophenone-2′,3′,4′,5′,6′-d5(2). (Reference: Challacombe, K.; Leach, SE; Plackett, SJ; Meakins, GDJ Chem.Soc.Perkin Trans.1 1988,2213-2218.) In a 2L round bottom three-neck flask, a mechanical A stirrer, dropping funnel and reflux condenser connected to a gas…